胶原/胶原肽螯合生物可及性金属的研究进展

doi:10.19677/j.issn.1004-7964.2023.05.008

皮革科学与工程 ›› 2023, Vol. 33 ›› Issue (5): 48-54.doi: 10.19677/j.issn.1004-7964.2023.05.008

胶原/胶原肽螯合生物可及性金属的研究进展

李盛龙, 曹珊^*, 王新德, 姬明宇

齐鲁工业大学（山东省科学院）轻工学部,山东济南 250353

收稿日期:2022-11-17 出版日期:2023-10-01 上线日期:2023-09-20
通讯作者: *曹珊（1988-）,女,博士,副教授,主要研究方向：制革清洁生产及废弃物处理。E-mail:cs1988@foxmail.com。
作者简介:李盛龙（2000-）,男,研究生,主要研究方向:胶原材料的开发及应用。E-mail:15763669705@163.com。
基金资助:
山东省齐鲁工业大学（山东省科学院）科教产融合试点工程基础研究类项目（2022PY038）

Research Progress on Collagen/collagen Peptide Chelated with Bio-Accessible Metals

LI Shenglong, CAO Shan^*, WANG Xinde, JI Mingyu

Faculty of Light Industry, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China

Received:2022-11-17 Online:2023-10-01 Published:2023-09-20

摘要/Abstract

摘要： 胶原蛋白作为哺乳动物体内含量最多的功能蛋白,具有亲水性、生物相容性与可生物降解性等优异特性。此外,胶原蛋白降解后可获得相对分子质量较小的胶原肽,其更容易被吸收利用。金属离子的存在对于生物体的生存不可或缺,人体必须金属元素如钙、铁、锰、铬、铜、锌等与胶原的结合机制长久以来一直备受关注;近年来,钛、锆、铝等金属的生物亲和性也逐渐开始受到关注。当胶原或胶原肽与金属元素进行螯合时,金属的特性通常会赋予螯合物较好的结构稳定性和特殊的理化性质。文章对胶原/胶原肽螯合生物可及性金属后获得的螯合物特性进行了总结,重点介绍了胶原及胶原肽与多种金属的结合机制及应用特性,并为胶原/胶原肽金属螯合物的应用提供参考依据。

关键词: 胶原, 胶原肽, 生物可及性金属, 螯合特性, 螯合物

Abstract: As the most abundant functional protein in mammals, collagen has excellent characteristics such as hydrophilicity, biocompatibility and biodegradability. In addition, collagen peptides with smaller molecular weights can be obtained after the degradation of collagen, which are easier to be absorbed and utilized. The presence of metal ions is indispensable for the survival of living organisms. The binding mechanisms of essential metal elements, such as calcium, iron, manganese, chromium, copper and zinc, with collagen have attracted attention for a long time. In recent years, the biological affinity of metals such as titanium, zirconium, and aluminum has gradually attracted attention. After collagen or collagen peptides are chelated with metal elements, the obtained chelating peptides usually have good structural stability and special physicochemical performance due to the properties of metals. This article summarized the characteristics of chelates obtained by the chelation of collagen/collagen peptide and bio-accessible metals, and the focus was played on their binding mechanisms and application characteristics. This review can provide a reference for the application of collagen/collagen peptide metal chelates.

Key words: collagen, collagen peptides, bio-accessible metals, chelating properties, chelates

中图分类号:

TS512

李盛龙, 曹珊, 王新德, 姬明宇. 胶原/胶原肽螯合生物可及性金属的研究进展[J]. 皮革科学与工程, 2023, 33(5): 48-54.

LI Shenglong, CAO Shan, WANG Xinde, JI Mingyu. Research Progress on Collagen/collagen Peptide Chelated with Bio-Accessible Metals[J]. Leather Science and Engineering, 2023, 33(5): 48-54.

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胶原/胶原肽螯合生物可及性金属的研究进展

Research Progress on Collagen/collagen Peptide Chelated with Bio-Accessible Metals

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