3D打印胶原基材料及其在口腔组织再生修复中的应用

doi:10.19677/j.issn.1004-7964.2023.02.008

皮革科学与工程 ›› 2023, Vol. 33 ›› Issue (2): 47-54.doi: 10.19677/j.issn.1004-7964.2023.02.008

3D打印胶原基材料及其在口腔组织再生修复中的应用

曾奕苇¹, 刘海², 沙川路², 周加境², 李蕙^1,*

1.四川大学华西口腔医学院,四川成都 610041;
2.四川大学轻工科学与工程学院,四川成都 610065

收稿日期:2023-02-06 出版日期:2023-04-01 上线日期:2023-03-21
通讯作者: *李蕙,E-mail:drlihui@outlook.com。
作者简介:曾奕苇（1998-）,女,博士研究生。E-mail:zyw95@foxmail.com。
基金资助:
国家自然科学基金项目（82100961）; 四川省自然科学基金项目（青年科学基金项目）（22NSFSC2583）

3D Printing of Collagen-based Materials and its Application in Regeneration and Repair of Oral Tissue

ZENG Yiwei¹, LIU Hai², SHA Chuanlu², ZHOU Jiajing², LI Hui^1,*

1. West China school of Stomatology, Sichuan University, Chengdu 610041, China;
2. College of Biomass Science and Engineering, Sichuan University, Chengdu 610065, China

Received:2023-02-06 Online:2023-04-01 Published:2023-03-21

摘要/Abstract

摘要： 3D打印技术可以通过精确控制细胞和生物材料的组成以及空间分布形态,制造用于促进组织修复再生的支架。胶原蛋白是动物组织中细胞外基质的重要成分,因其优异的生物相容性,已经被用于多种组织再生的3D打印生物墨水。口腔及颅颌面组织的缺损会对患者的口腔功能和外貌产生巨大影响,然而,当前临床治疗方法并不能完全恢复其原有的解剖结构和生理功能。文章综述了当前常用的生物3D打印技术、胶原蛋白的来源及提取方法、载细胞与无细胞的3D打印胶原基材料的制备。同时,归纳了3D打印胶原基材料在牙髓-牙本质复合体、牙周组织、骨、软骨、皮肤再生等口腔医学中应用,对胶原基材料在口腔健康领域的应用进行了展望。

关键词: 3D打印, 胶原蛋白, 口腔组织再生, 组织工程, 牙髓-牙本质复合体, 牙周再生, 骨再生

Abstract: 3D printing can be used to create scaffolds for promoting tissue repair and regeneration by precisely controlling the composition and spatial distribution patterns of cells and biomaterials. Collagen, an important component of the extracellular matrix in animal tissues, has been used as a 3D printing bioink for a variety of tissue regeneration due to its excellent biocompatibility. Defects in oral and craniomaxillofacial tissue can have a significant impact on the function and appearance of patients. However, current clinical treatments cannot restore their original anatomical structure and physiological function completely. This article reviews the current commonly used 3D bioprinting technologies, and the sources and extraction methods of collagen, cell-laden and cell-free collagen-based bioinks. The applications of 3D printed collagen-based materials in pulp-dentin complexes, periodontal tissues, bone, cartilage, and skin regeneration are highlighted. We also envision the future development of collagen-based bioinks for biomedicine applications.

Key words: 3D printing, collagen, oral tissue regeneration, tissue engineering, pulp-dentin complexes, periodontal regeneration, bone regeneration

中图分类号:

曾奕苇, 刘海, 沙川路, 周加境, 李蕙. 3D打印胶原基材料及其在口腔组织再生修复中的应用[J]. 皮革科学与工程, 2023, 33(2): 47-54.

ZENG Yiwei, LIU Hai, SHA Chuanlu, ZHOU Jiajing, LI Hui. 3D Printing of Collagen-based Materials and its Application in Regeneration and Repair of Oral Tissue[J]. Leather Science and Engineering, 2023, 33(2): 47-54.

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3D打印胶原基材料及其在口腔组织再生修复中的应用

3D Printing of Collagen-based Materials and its Application in Regeneration and Repair of Oral Tissue

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