皮革科学与工程 ›› 2022, Vol. 32 ›› Issue (4): 14-19.doi: 10.19677/j.issn.1004-7964.2022.04.003

• 试验研究 • 上一篇    下一篇

衣康酸酐改性胶原制备光固化水凝胶

程玉林1,2, 李国英1,2,*   

  1. 1.四川大学制革清洁技术国家工程实验室,四川 成都 610065;
    2.四川大学皮革化学与工程教育部重点实验室,四川 成都 610065
  • 收稿日期:2022-02-12 出版日期:2022-08-28 上线日期:2022-07-11
  • 通讯作者: *李国英(1967-),女,教授,博士生导师,E-mail:liguoyings@163.com。
  • 作者简介:程玉林(1997-),女,在读硕士研究生,E-mail:cheng.yulin@foxmail.com。
  • 基金资助:
    国家自然科学基金资助项目(22078206)

Preparation of Photocurable Hydrogel by Modifying Collagen with Itaconic Anhydride

CHENG Yulin1,2, LI Guoying1,2,*   

  1. 1. National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University, Chengdu 610065, China;
    2. Key Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Chengdu 610065, China
  • Received:2022-02-12 Online:2022-08-28 Published:2022-07-11

摘要: 用衣康酸酐改性胶原,再通过紫外光照射制备光固化水凝胶,并研究了取代度对该光固化凝胶性能的影响,在此基础上确定了衣康酸酐最佳取代度。结果显示,随着衣康酸基团取代度增加,成胶时间延长,凝胶的孔径变小,而凝胶的流变性和溶胀性先增加后减小,此外,凝胶的抑菌性与取代度呈正相关。衣康酸酐的最佳取代度为70.4%,此时凝胶固化所需时间为150 s,同时凝胶储能模量和损耗模量最高,分别为358.07 Pa和45.93 Pa,溶胀率高达37.65,且具有一定的抑菌性。研究制备的光固化水凝胶有较高的溶胀性和机械强度还具备一定的抗菌性,可用于开发伤口敷料。关键词:胶原;衣康酸酐;光固化;水凝胶

关键词: 胶原, 衣康酸酐, 光固化, 水凝胶

Abstract: Collagen was modified with itaconic anhydride and photocurable hydrogel was prepared by uv irradiation. Simultaneously, the influence of substitution degree on the properties of the photocurable hydrogel was studied. On this basis, the optimal substitution degree of itaconic anhydride was determined. The results showed that with the increase of substitution degree, the hydrogel formation time was prolonged and the pore size decreased, while the rheology and swelling of the hydrogel increased first and then decreased. In addition, the bacteriostasis of the hydrogel was positively correlated with the substitution degree. The optimum substitution degree of itaconic anhydride was 70.4%, and the curing time was 150 s. Meanwhile, the storage modulus and loss modulus of hydrogel were the highest, which were 358.07 Pa and 45.93 Pa respectively. Moreover, the swelling rate was as high as 37.65, and the hydrogel had certain bacteriostasis. The photocurable hydrogel prepared in this study has high swelling and mechanical strength and simultaneously certain antibacterial properties, which can be used to develop wound dressings.

Key words: collagen, itaconic anhydride, photocurable, hydrogel

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