胶原化学改性及应用进展

doi:10.19677/j.issn.1004-7964.2023.05.007

皮革科学与工程 ›› 2023, Vol. 33 ›› Issue (5): 40-47.doi: 10.19677/j.issn.1004-7964.2023.05.007

胶原化学改性及应用进展

白忠薛^1,3, 王学川^1,2,3,*, 李彤^2,3, 李佳俊^1,3, 冯宇宇^1,3, 黄梦晨¹, 岳欧阳^1,3, 刘新华^1,2,3,*

1.陕西科技大学轻工科学与工程学院轻化工程国家级实验教学示范中心,陕西西安 710021;
2.陕西科技大学化学与化工学院,陕西西安 710021;
3.陕西科技大学生物质与功能材料研究所,陕西西安 710021

收稿日期:2022-12-08 出版日期:2023-10-01 上线日期:2023-09-20
通讯作者: *王学川（1963-）,男,教授,研究方向为清洁化制革/毛皮/合成革生产技术与理论、生物质资源化及胶原基质生物医用材料、环保型绿色轻纺助剂精细化学品的制备及其作用机理研究、功能高分子材料的结构设计及性能研究等。E-mail：wangxc@sust.edu.cn;刘新华（1991-）,男,副教授,主要研究方向为胶原基质生物医用材料、柔性电子传感材料、先进皮革生态化学品等。E-mail：liuxinhua@sust.edu.cn。
作者简介:白忠薛（1995-）,男,博士研究生,主要研究方向为生物质基多功能柔性传感材料。E-mail:18292001608@163.com。
基金资助:
国家自然科学基金（2207081675、22278257）; 中国博士后科学基金（2021M692000）; 陕西省重点研发计划（2022GY-272）; 陕西省高校科协青年人才支持计划项目（20200424）; 教育厅产学研结合创新资助-2018年“蓝火计划（惠州）”（CXZJHZ201801）

Chemical Modification and Application Advances of Collagen

BAI Zhongxue^1,3, WANG Xuechuan^1,2,3,*, LI Tong^2,3, LI Jiajun^1,3, FENG Yuyu^1,3, HUANG Mengchen¹, YUE Ouyang^1,3, LIU Xinhua^1,2,3,*

1. College of Bioresources Chemical and Materials Engineering, National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science & Technology, Xi’an, Shaanxi 710021, China;
2. College of Chemistry and Chemical Engineering, Shaanxi University of Science & Technology, Xi’an, Shaanxi 710021, China;
3. Institute of Biomass & Functional Materials, Shaanxi University of Science & Technology, Xi’an, Shaanxi 710021, China

Received:2022-12-08 Online:2023-10-01 Published:2023-09-20

摘要/Abstract

摘要： 胶原是动物组织中含量最高和分布最广的一类蛋白质,按发现顺序分为I型胶原、II型胶原、III型胶原等,其中最常见的为I型胶原。胶原具有良好的生物相容性、可降解性、低抗原性以及物理机械性能等,近年来被广泛应用于食品、生物材料、畜牧业、医美等多个领域。文章介绍了不同改性剂对胶原化学改性的特点,包括戊二醛、壳聚糖、京尼平、碳化二亚胺以及聚乙二醇等。同时,归纳了胶原在医疗美容、食品、柔性电子材料等领域的应用研究进展。最后,对胶原未来的推广应用进行了展望。

关键词: 胶原, 化学改性, 医药, 食品, 柔性电子材料

Abstract: As one of the most abundant and widely distributed functional proteins in animal tissues and organs, collagen can be classified into types I, II, and III in the order of discovery, with type I collagen being the most common one. Collagen possesses good biocompatibility and degradability as well as low antigenicity, physical and mechanical properties, and has been widely used in recent years in many fields, such as food, biomaterials, animal husbandry, and medical aesthetics. In this paper, the chemical characteristics of modified collagen by different agents were introduced, including glutaraldehyde, chitosan, genipin, carbodiimide, and polyethylene glycol. Meanwhile, the application advances of collagen in the fields of medicine, cosmetics, food, and flexible electronic materials were summarized. Finally, the future promotion and application of collagen was prospected.

Key words: collagen, chemical modification, medicine, food, flexible electronic materials

中图分类号:

S879.9
TQ932

白忠薛, 王学川, 李彤, 李佳俊, 冯宇宇, 黄梦晨, 岳欧阳, 刘新华. 胶原化学改性及应用进展[J]. 皮革科学与工程, 2023, 33(5): 40-47.

BAI Zhongxue, WANG Xuechuan, LI Tong, LI Jiajun, FENG Yuyu, HUANG Mengchen, YUE Ouyang, LIU Xinhua. Chemical Modification and Application Advances of Collagen[J]. Leather Science and Engineering, 2023, 33(5): 40-47.

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胶原化学改性及应用进展

Chemical Modification and Application Advances of Collagen

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