刺激响应型抗菌剂研究进展及在胶原抗菌防腐中应用展望

doi:10.19677/j.issn.1004-7964.2022.02.007

皮革科学与工程 ›› 2022, Vol. 32 ›› Issue (2): 40-46.doi: 10.19677/j.issn.1004-7964.2022.02.007

刺激响应型抗菌剂研究进展及在胶原抗菌防腐中应用展望

孙莎莎, 侯德隆, 杨高夫, 陈意^*

四川大学轻工科学与工程学院,四川成都 610065

收稿日期:2021-08-04 出版日期:2022-04-28 上线日期:2022-03-22
通讯作者: *陈意（1983-）,男,教授,chenyi_leon@scu.edu.cn,主要从事生物质高值利用研究。
作者简介:孙莎莎（1996-）,女,硕士研究生,1961913527@qq.com。
基金资助:
国家自然科学基金（21878196）; 四川省科技计划面上项目（2020YJ0315）

A Review on Progress of Stimulus-Responsive Antibacterial Agents and their Potential Application in Collagen

SUN Shasha, HOU Delong, YANG Gaofu, CHEN Yi^*

College of Biomass Science and Engineering, Sichuan University, Chengdu 610065, China

Received:2021-08-04 Published:2022-04-28 Online:2022-03-22

摘要/Abstract

摘要： 胶原作为一种结构独特、功能多样、生物相容性优良的天然生物质材料,在当代组织工程、医美等领域应用广泛。然而,天然胶原极易受微生物侵蚀,虽然通过外添加抗菌剂可解决这一问题,但传统抗菌剂不仅会损坏胶原生物相容性,其环境累积还可能导致耐药性产生。过去十年间,科研工作者致力于开发各种刺激响应型抗菌剂,其抗菌活性受外界条件控制可按需开关,能有效规避抗菌剂毒副作用并抑制耐药性产生。本文在总结目前国内外刺激响应型抗菌剂研究成果的基础上,对这类智能材料在胶原抗菌防腐中的应用进行展望。

关键词: 胶原, 抗菌, 刺激响应

Abstract: As a natural biomass material with unique structure, diverse functions and excellent biocompatibility, collagen is widely used in various fields such as tissue engineering and medical cosmetology. However, naturally-occurring collagen is susceptible to microbial contamination. Although this problem can be solved by adding antibacterial agents, traditional antibacterial agents will damage the inherent biocompatibility of collagen, and their accumulation in the environment may also lead to microbial resistance. Over the past 10 years, great achievement has been made to develop various stimulus-responsive antibacterial agents, whose bioactivity can be controlled by external stimulus and thus can be switched on and off on demand. Such function is of potential to avoid the side effects of antibacterial agents and inhibit the occurrence of microbial resistance. This review summarizes the research progress of stimulus-responsive antibacterial agents worldwide, and prospects the application of these intelligent materials in collagen.

Key words: collagen, antibacterial, stimulus-responsive

中图分类号:

TQ512

孙莎莎, 侯德隆, 杨高夫, 陈意. 刺激响应型抗菌剂研究进展及在胶原抗菌防腐中应用展望[J]. 皮革科学与工程, 2022, 32(2): 40-46.

SUN Shasha, HOU Delong, YANG Gaofu, CHEN Yi. A Review on Progress of Stimulus-Responsive Antibacterial Agents and their Potential Application in Collagen[J]. Leather Science and Engineering, 2022, 32(2): 40-46.

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刺激响应型抗菌剂研究进展及在胶原抗菌防腐中应用展望

A Review on Progress of Stimulus-Responsive Antibacterial Agents and their Potential Application in Collagen

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