超高效液相色谱-串联质谱法测定皮革中9种双酚类物质

doi:10.19677/j.issn.1004-7964.2024.03.009

Leather Science and Engineering ›› 2024, Vol. 34 ›› Issue (3): 58-65.doi: 10.19677/j.issn.1004-7964.2024.03.009

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Determination of 9 Bisphenols in Leather by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry

WANG Ning^*, ZHOU Lei, ZHANG Huansheng, HU Xiuhong, MIAO Jie

Wenzhou Quality and Technology Testing Research Institute, Wenzhou 325000, China

Received:2023-12-18 Revised:2024-01-25 Accepted:2024-01-27 Published:2024-06-01 Online:2024-04-25

Abstract

Abstract: A method for simultaneous determination of 9 bisphenols in leather was established by ultra-high performance liquid chromatography-tandem mass spectrometry. The sample was ultrasonically extracted with methanol. The obtained extract was purified by solid phase extraction column and concentrated to constant volume. The filtrated solution was separated by Agilent ZORBAX Eclipse Plus C18 chromatographic column (100 mm×3.0 mm, 3.5 μm), using water-methanol as mobile phases for gradient elution. Multi-reaction monitoring analysis was performed using a quadrupole mass spectrometer, and internal standard method was adopted for quantification. The results showed that the 9 bisphenols could be separated within 9 min, and the good linear relationships were obtained with correlation coefficients R2 all above 0.999 0. The limits of detection and quantification were in the ranges of 0.8-24 μg/kg and 4.0-80 μg/kg, respectively. The average recoveries were 85.2%-105.6% with precisions of 2.6%-10.3%. Bisphenol F, bisphenol S, bisphenol A, bisphenol E and bisphenol AF were detected in the leathers for shoes, with the higher detection rates for bisphenol F and bisphenol S, respectively. With the advantages of convenient operation, high sensitivity and good precision, the method provides a technical support for risk monitoring of bisphenols in leather and leather goods.

Key words: liquid chromatography-tandem mass spectrometry, leather, bisphenols, endocrine disrupting compounds

CLC Number:

TS943.79

WANG Ning, ZHOU Lei, ZHANG Huansheng, HU Xiuhong, MIAO Jie. Determination of 9 Bisphenols in Leather by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry[J]. Leather Science and Engineering, 2024, 34(3): 58-65.

References

[1] 田姝,李海,蒋洁蓉,等.皮革中双酚A的含量测定-高效液相色谱法[J].皮革与化工,2022,39(6):12-15,43.
TIAN S,LI H,JIANG J R,et al.Determination of the migration amount for the bisphenol A(BPA)in leather by HPLC[J].Leather Chem,2022,39(6):12-15,43.(in Chinese)
[2] WOZNIAK A L,BULAYEVA N N,WATSON C S.Xenoestrogens at picomolar to nanomolar concentrations trigger membrane estrogen receptor-α-mediated Ca2+ fluxes and prolactin release in GH3/B6 pituitary tumor cells[J].Environ Health Persp,2005,113(4):431-439.
[3] LEE H J,CHATTOPADHYAY S,GONG E Y,et al.Antiandrogenic effects of bisphenol A and nonylphenol on the function of androgen receptor[J].Toxicol Sci,2003,75(1):40-46.
[4] MICHAŁOWICZ J.Bisphenol A-Sources,toxicity and biotransformation[J].Environ Toxicol Phar,2014,37(2):738-758.
[5] WU L H,ZHANG X M,WANG F,et al.Occurrence of bisphenol S in the environment and implications for human exposure:a short review[J].Sci Total Environ,2018,615:87-98.
[6] BANADERAKHSHAN R,KEMP P,BREUL L,et al.Bisphenol A and its alternatives in Austrian thermal paper receipts,and the migration from reusable plastic drinking bottles into water and artificial saliva using UHPLC-MS/MS[J].Chemosphere,2022,286:131842.
[7] BOUSOUMAH R,LESO V,IAVICOLI I,et al.Biomonitoring of occupational exposure to bisphenol A,bisphenol S and bisphenol F:a systematic review[J].Sci Total Environ,2021,783:146905.
[8] MAO J D,JAIN A,DENSLOW N D,et al.Bisphenol A and bisphenol S disruptions of the mouse placenta and potential effects on the placenta-brain axis[J].Proc Natl Acad Sci USA,2020,117(9):4642-4652.
[9] LIN J T,DENG L J,SUN M W,et al.An in vitro investigation of endocrine disrupting potentials of ten bisphenol analogues[J].Steroids,2021,169:108826.
[10] IKHLAS S,USMAN A,AHMAD M.In vitro study to evaluate the cytotoxicity of BPA analogues based on their oxidative and genotoxic potential using human peripheral blood cells[J].Toxicol in Vitro,2019,60:229-236.
[11] CATENZA C J,FAROOQ A,SHUBEAR N S,et al.A targeted review on fate,occurrence,risk and health implications of bisphenol analogues[J].Chemosphere,2021,268:129273.
[12] WANG Q X,FENG Q Y,HU G J,et al.Simultaneous determination of seven bisphenol analogues in surface water by solid-phase extraction and ultra-performance liquid chromatography-tandem mass spectrometry[J].Microchem J,2022,175:107098.
[13] CHOI J Y,LEE J,HUH D A,et al.Urinary bisphenol concentrations and its association with metabolic disorders in the US and Korean populations[J].Environ Pollut,2022, 295:118679.
[14] LIU Y H,YAN Z Y,ZHANG Q,et al.Urinary levels,composition profile and cumulative risk of bisphenols in preschool- aged children from Nanjing suburb,China[J].Ecotoxicol Environ Safe,2019,172:444-450.
[15] JIN H B,XIE J H,MAO L L,et al.Bisphenol analogue concentrations in human breast milk and their associations with postnatal infant growth[J].Environ Pollut,2020,259:113779.
[16] BARBOZA L G A,CUNHA S C,MONTEIRO C,et al.Bisphenol A and its analogs in muscle and liver of fish from the North East Atlantic Ocean in relation to microplastic contamination.Exposure and risk to human consumers[J].J Hazard Mater,2020,393:122419.
[17] WANG Q,CHEN M,SHAN G Q,et al.Bioaccumulation and biomagnification of emerging bisphenol analogues in aquatic organisms from Taihu Lake,China[J].Sci Total Environ,2017,598:814-820.
[18] GEENS T,NEELS H,COVACI A.Distribution of bisphenol-A,triclosan and n-nonylphenol in human adipose tissue,liver and brain[J].Chemosphere,2012,87(7):796-802.
[19] GALLO P,DI MARCO PISCIOTTANO I,FATTORE M,et al.A method to determine BPA,BPB,and BPF levels in fruit juices by liquid chromatography coupled to tandem mass spectrometry[J].Food Addit Contam A,2019,36(12):1871-1881.
[20] 赵斌,谭学蓉,付瑜,等.基于QuEChERS的超高效液相色谱-串联质谱法快速测定果蔬中双酚类物质[J].分析化学,2022,50(5):810-818.
ZHAO B,TAN X R,FU Y,et al.Rapid determination of bisphenols in fruits and vegetables by QuEChERS-ultra-high performance liquid chromatography-tandem mass spectrometry[J].Chin J Anal Chem,2022,50(5):810-818.(in Chinese)
[21] 韩疏影,宋易霖,康安,等.在线富集与高效液相色谱-荧光检测法联用同时检测儿童水杯中9种双酚类物质[J].色谱,2019,37(11):1185-1192.
HAN S Y,SONG Y L,KANG A,et al.Determination of nine bisphenols in children’s water bottle by online enrichment coupled with high performance liquid chromatography-fluorescence detection[J].Chin J Chromatogr,2019,37(11):1185-1192.(in Chinese)
[22] LIAO C Y,LIU F,KANNAN K.Bisphenol S,a new bisphenol analogue,in paper products and currency bills and its association with bisphenol A residues[J].Environ Sci Technol,2012,46(12):6515-6522.
[23] 蒋小良,陈梅,陈凯,等.微波萃取/GC-MS测定纸质食品包装材料中双酚A[J].中华纸业,2014,35(6):26-29.
JIANG X L,CHEN M,CHEN K,et al.Determination of bisphenol A in paper packaging material for foodstuffs by microwave extraction and GC-MS[J].China Pulp Paper Ind,2014,35(6):26-29.(in Chinese)
[24] SOUZA J M O,SOUZA M C O,ROCHA B A,et al.Levels of phthalates and bisphenol in toys from Brazilian markets:migration rate into children's saliva and daily exposure[J].Sci Total Environ,2022,828:154486.
[25] 姜士磊,张璐燕,项伟,等.超声萃取-高效液相色谱法检测塑料玩具中双酚A及其类似物[J].分析测试技术与仪器,2021,27(1):24-29.
JIANG S L,ZHANG L Y,XIANG W,et al.Determination of bisphenol A and its analogues in plastic toys by high performance liquid chromatography coupled with ultrasonic extraction[J].Anal Test Technol Instrum,2021,27(1):24-29.(in Chinese)
[26] 邱月,李根容,龙梅,等.超高效合相色谱法同时检测塑料食品接触材料中11种双酚类化合物[J].分析化学,2020,48(2):255-261.
QIU Y,LI G R,LONG M,et al.Determination of 11 kinds of bisphenols in plastic food contact materials by ultra-performance convergence chromatography[J].Chin J Anal Chem,2020,48(2):255-261.(in Chinese)
[27] WANG R G,DONG S J,WANG P L,et al.Development and validation of an ultra performance liquid chromatography-tandem mass spectrometry method for twelve bisphenol compounds in animal feed[J].J Chromatogr B,2021,1178:122613.
[28] 张爱玉,邓旭山,陈涛,等.顶空固相微萃取-气相色谱-质谱法测定皮革中的富马酸二甲酯[J].现代纺织技术,2021,29(4):86-90.
ZHANG A Y,DENG X S,CHEN T,et al.Determination of dimethyl fumarate in leathers by headspace solid -phase microextraction-gas chromatography-mass spectrometry[J]. Adv Text Technol,2021,29(4):86-90.(in Chinese)
[29] 吴泽颖,裴文艺,毕中昱,等.皮革制品中光引发剂含量的测定[J].皮革科学与工程,2021,31(1):60-64.
WU Z Y,PEI W Y,BI Z Y,et al.Determination of photoinitiators in leather products[J].Leather Sci Eng,2021,31(1):60-64.(in Chinese)
[30] 王成云,李丽霞,谢堂堂,等.超声萃取-气相色谱-串联质谱法同时测定皮革及其制品中21种有害有机溶剂的残留量[J].质谱学报,2016,37(2):121-133.
WANG C Y,LI L X,XIE T T,et al.Simultaneous determination of the residual contents of 21 harmful organic solvents in leather and leather products by GC-MS/MS coupled with ultrasonic extraction[J].J Chin Mass Spectrom Soc,2016,37(2):121-133.(in Chinese)
[31] 陆静,付善良,成婧,等.顶空GC-MS测定皮革及其制品中的9种溶剂残留[J].皮革科学与工程,2021,31(1):54-59.
LU J,FU S L,CHENG J,et al.Determination of 9 organic solvent residues in leather and its products by headspace-GC- MS spectrometry[J].Leather Sci Eng,2021,31(1):54-59.(in Chinese)
[32] 严方平,刘秋香,毛世南,等.皮革中双酚A的高效液相色谱测定方法研究[J].中国皮革,2023,52(10):8-11.
YAN F P,LIU Q X,MAO S N,et al.Determination of bisphenol A in leather by high performance liquid chromatography[J].China Leather,2023,52(10):8-11.(in Chinese)
[33] 张明霞,杨耀武,霍江莲,等.GB/T 27417-2017合格评定化学分析方法确认和验证指南[S].北京:中国标准出版社,2017.
ZHANG M X,YANG Y W,HUO J L,et al.GB/T 27417-2017 Comformity assessment-Guidance on validation and verification of chemical analytical methods[S].Beijing:Standards Press of China,2017.(in Chinese)

Determination of 9 Bisphenols in Leather by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry

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