Cr(III)和Cr(VI)的表观遗传毒性分析

doi:10.19677/j.issn.1004-7964.2022.04.008

皮革科学与工程 ›› 2022, Vol. 32 ›› Issue (4): 47-53.doi: 10.19677/j.issn.1004-7964.2022.04.008

Cr(III)和Cr(VI)的表观遗传毒性分析

王琴^1,2, 何云翔², 龚贵东², 杨斌¹, 王楠¹, 张曜耀³, 顾健^1,*

1.西南民族大学药学院,四川成都610225;
2.四川大学轻工科学与工程学院,四川成都610065;
3.四川大学华西第二医院妇产科生殖医学中心,四川成都610041

收稿日期:2021-10-12 出版日期:2022-08-28 上线日期:2022-07-11
通讯作者: *gujiancd@163.com
作者简介:王琴（1991-）,女,博士研究生,博士后,讲师,表观遗传学,E-mail: jiajiawangqin@163.com。
基金资助:
中央高校基本科研业务费专项基金项目青年成长项目“ 结肠癌中组蛋白修饰抑制SARI 基因转录的机理研究”（2020NQN39）

Epigenetic Toxicity Analysis of Cr(III) and Cr(VI)

WANG Qin^1,2, HE Yunxiang², GONG Guidong², YANG Bin¹, WANG Nan¹, ZHANG Yaoyao³, GU Jian^1,*

1. School of Pharmacy, Southwest Minzu University, Chengdu 610225, China;
2. College of Biomass Science and Engineering, Sichuan University, Chengdu 610065, China;
3. Reproductive Center, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China

Received:2021-10-12 Online:2022-08-28 Published:2022-07-11

摘要/Abstract

摘要： 铬是一种人体的必需微量元素,其存在的价态与其对人体的效用存在密切联系。三价铬是铬在自然界中最稳定的化合态,可作为胰岛素的协助因子参与调控体内糖、脂肪和蛋白质的代谢,对人体没有表观遗传毒性。而六价铬为致癌物,可通过干扰DNA 甲基化、组蛋白修饰、染色体重塑和非编码RNA 调控等表观遗传模式对人体健康造成严重威胁。综述对充分认识三价铬的生物学功能和六价铬的表观遗传毒性有重要的意义。

关键词: 院铬, 微量元素, 胰岛素, 表观遗传

Abstract: Chromium is an essential trace element in human body, and its ion valence state is closely related to its effect on human body. Trivalent chromium is the most stable state of chromium in nature. It can be used as a co-factor of insulin to regulate the metabolism of sugar, fat and protein, and has no epigenetic toxicity to human body. Howerver, hexavalent chromium, a carcinogen, poses a serious threat to human health by interfering with epigenetic patterns such as DNA methylation, histone modification, chromosomal remodeling and non-coding RNA regulation. This review is of great significance to fully understand the biological functions of trivalent chromium and the epigenetic toxicity of hexavalent chromium.

Key words: chromium, trace element, insulin, epigenetic

中图分类号:

R394.3

王琴, 何云翔, 龚贵东, 杨斌, 王楠, 张曜耀, 顾健. Cr(III)和Cr(VI)的表观遗传毒性分析[J]. 皮革科学与工程, 2022, 32(4): 47-53.

WANG Qin, HE Yunxiang, GONG Guidong, YANG Bin, WANG Nan, ZHANG Yaoyao, GU Jian. Epigenetic Toxicity Analysis of Cr(III) and Cr(VI)[J]. Leather Science and Engineering, 2022, 32(4): 47-53.

参考文献

[1] Mertz W, Roginski E E, Schwarz K.Effect of trivalent chromium complexes on glucose uptake by epididymal fat tissue of rats[J]. The Journal of Biological Chemistry, 1961, 236(2): 318-322.
[2] Mertz W.Chromium Occurrenceand Function in Biological Systems[J]. Physiological Reviews, 1969, 49(2): 163-239.
[3] 王学川,程正平,丁志文,等.我国危险废物管理制度与含铬皮革废料的管理现状及建议[J].皮革科学与工程,2020,30(02):42-247.
[4] MachniK M, Oleksiewicz U. Dynamic Signatures of the Epigenome: Friend or Foe?[J]. Cells, 2020, 9(3): 653.
[5] Oleksiewicz U, Machnik M.Causes, effects, and clinical implications of perturbed patterns within the cancer epigenome[J]. Seminars in Cancer Biology, 2020, (20): 30274-1.
[6] Hogg S J, Beavis P A, Dawson M A, et al.Targeting the epigenetic regulation of antitumour immunity[J]. Nature Reviews Drug Discovery, 2020, 19(11): 776-800.
[7] Jacobs J A, Testa S M.Overview of chromium(VI) in the environment: background and history[J]. 2005.
[8] 刘志皋. 食品营养学[M].北京:中国轻工业出版社,2006:148-227.
[9] 高步先,夏耕田,张乃生.铬的生物学功能及其在动物体内的代谢[J].动物医学进展,2002,23(6):49-51.
[10] Vincent J B.The biochemistry of chromium[J].Journal of Nutrition,2000,130(4):715-718.
[11] Clodfelder B J,Upchurch R G,Vincent J B.A Comparison of the Insulin-Sensitive Transport of Chromium in Healthy and Model Diabetic Rats[J].Journal of inorganic biochemistry,2004,98(3):522-533.
[12] Wang S,Wang J,Liu Y J,et al.Trivalent Chromium Supplementation Ameliorates Oleic Acid-Induced Hepatic Steatosis in Mice[J].Biological Trace Element Research,2019,187(1):192-201.
[13] Schwarz K,Mertz W.Chromium(III)and the glucose tolerance factor[J].Archives of Biochemistry and Biophysics,1959,85(1):292-295.
[14] Leto D,Saltiel A R.Regulation of Glucose Transport by Insulin:Traffic Control of GLUT4[J].Nature Reviews Molecular Cell Biology,2012,13(6):383-396.
[15] Jain S K,Rains J L,Croad J L.Effect of chromium niacinate and chromium picolinate supplementation on lipid peroxidation,TNF-alpha,IL-6,CRP,glycated hemoglobin,triglycerides,and cholesterol levels in blood of streptozotocin-treated diabetic rats[J].Free Radical Biology Medicine,2007,43(8):1124-1131.
[16] 程南征,胡晓林,姜桂荣.糖尿病病人和健康人的血铬和尿铬含量[J].营养学报,1987,9(3):265-269.
[17] Petroni M L,Brodosi L,Marchignoli F,et al.Nutrition in Patients with Type 2 Diabetes:Present Knowledge and Remaining Challenges[J].Nutrients,2021,13(8):2748.
[18] Di Bona K R,Love S,Rhodes N R,et al.Chromium is not an essential trace element for mammals:effects of a"low-chromium"diet[J].Journal of Biological Inorganic Chemistry,2011,16(3):381-390.
[19] Pattar G R,Tackett L,Liu P,et al.Chromium picolinate positively influences the glucose transporter system via affecting cholesterol homeostasis in adipocytes cultured under hyperglycemic diabetic conditions[J].Mutation Research-Genetic Toxicology and Environmental Mutagenesis,2006,610(1-2):93-100.
[20] Chen W Y,Chen C J,Liu C H,et al.Chromium attenuates high-fat diet-induced nonalcoholic fatty liver disease in KK/HlJ mice[J].Biochemical Biophysical Research Communications,2010,397(3):459-464.
[21] 考庆君,吴坤.铬的生物学作用及毒性研究进展[J].中国公共卫生,2004,20(11):1398-1400.
[22] Peng Z L,Qiao W,Wang Z S,et al.Chromium Improves Protein Deposition through Regulating the mRNA Levels of IGF-1,IGF-1R,and Ub in Rat Skeletal Muscle Cells[J].Biological Trace Element Research,2010,137(2):226-234.
[23] Campbell W W,Joseph L J,Anderson R A,et al.Effects of resistive training and chromium picolinate on body composition and skeletal muscle size in older women[J].Journal of Applied Physiology,1999,86(1):29.
[24] Urone P F,Anders H K.Determination of Small Amounts of Chromium in Human Blood,Tissues,and Urine[J].Analytical Chemistry,1950,22(10):1317-1321.
[25] Liu Y,Zhao X,Zhang X,et al.Effects of Oral Administration of CrCl₃ on the Contents of Ca,Mg,Mn,Fe,Cu,and Zn in the Liver,Kidney,and Heart of Chicken[J].Biological Trace Element Research,2016,171(2):459-467.
[26] Fang Z,Zhao M,Zhen H,et al.Genotoxicity of tri-and hexavalent chromium compounds in vivo and their modes of action on DNA damage in vitro[J].PLoS One.2014,9(8):103194-103194.
[27] Abadin H,Smith C,Ingerman L,et al.Toxicological profile for RDX[J].Lancet,2012,243(6292):454-454.
[28] Azeez N A,Dash S S,Gummadi S N,et al.Nano-remediation of toxic heavy metal contamination:Hexavalent chromium[Cr(VI)][J].Chemosphere,2021,266:129204.
[29] Chen Q Y,Murphy A,Sun H,et al.Molecular and epigenetic mechanisms of Cr(VI)-induced carcinogenesis[J].Toxicology Applied Pharmacology,2019,377:114636.
[30] Sun H,Brocato J,Costa M.Oral Chromium Exposure and Toxicity[J].Current Environmental Health Reports,2015,2(3):295-303.
[31] Zhitkovich A.Importance of chromium-DNA adducts in mutagenicity and toxicity of chromium(VI)[J].Chemical Research in Toxicology,2005,18(1):3-11.
[32] O'brien T J,Ceryak S,Patierno S R.Complexities of chromium carcinogenesis:role of cellular response,repair and recovery mechanisms[J].Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis,2003,533(1-2):3-36.
[33] Nickens K P,Patierno S R,Ceryak S.Chromium genotoxicity:A double-edged sword[J].Chemico-Biological Interactions,2010,188(2):276-88.
[34] Zhang Y,Zheng P,Su Z,et al.Perspectives of Genetic Damage and Epigenetic Alterations by Hexavalent Chromium:Time Evolution Based on a Bibliometric Analysis[J].Chemical Research in Toxicology,2021,34(3):684-694.
[35] Wu H,Zhang Y.Reversing DNA methylation:mechanisms,genomics,and biological functions[J].Cell,2014,156(1-2):45-68.
[36] Jones P A.Functions of DNA methylation:islands,start sites,gene bodies and beyond[J].Nature Reviews Genetics,2012,13(7):484-492.
[37] Shen H,Laird P W.Interplay between the cancer genome and epigenome[J].Cell,2013,153(1):38-55.
[38] Klein C B,Su L,Bowser D,et al.Chromate-induced epimutations in mammalian cells[J].Environmental Health Perspectives,2002,110 Suppl 5:739-743.
[39] Wang Y,Wu W,Yao C,et al.Elevated tissue Cr levels,increased plasma oxidative markers,and global hypomethylation of blood DNA in male Sprague-Dawley rats exposed to potassium dichromate in drinking water[J].Environmental Toxicology,2016,31(9):1080-1090.
[40] Tsuboi M,Kondo K,Soejima S,et al.Chromate exposure induces DNA hypermethylation of the mismatch repair gene MLH1 in lung cancer[J].Molecular Carcinogenesis,2020,59(1):24-31.
[41] Kondo K,Takahashi Y,Hirose Y,et al.The reduced expression and aberrant methylation of p16(INK4a)in chromate workers with lung cancer[J].Lung Cancer,2006,53(3):295-302.
[42] Hu G,Li P,Cui X,et al.Cr(VI)-induced methylation and down-regulation of DNA repair genes and its association with markers of genetic damage in workers and 16HBE cells[J].Environmental Pollution,2018,238:833-843.
[43] Wang Y,Su H,Gu Y,et al.Carcinogenicity of chromium and chemoprevention:a brief update[J].Oncotargets and Therary,2017,10:4065-4079.
[44] Chia N,Wang L,Lu X,et al.Hypothesis:environmental regulation of 5-hydroxymethylcytosine by oxidative stress[J].Epigenetics,2011,6(7):853-856.
[45] Valinluck V,Sowers L C.Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1[J].Cancer Research,2007,67(3):946-950.
[46] Martire S,Banaszynski L A.The roles of histone variants in fine-tuning chromatin organization and function[J].Nature Reviews Molecular Cell Biology,2020,21(9):522-541.
[47] Ho T C S,Chan A H Y,Ganesan A.Thirty Years of HDAC Inhibitors:2020 Insight and Hindsight[J].Journal of Medicinal Chemistry,2020,63(21):12460-12484.
[48] Kouzarides T.Chromatin modifications and their function[J].Cell,2007,128(4):693-705.
[49] Xia B,Ren X H,Zhuang Z X,et al.Effect of hexavalent chromium on histone biotinylation in human bronchial epithelial cells[J].Toxicology Letters,2014,228(3):241-247.
[50] Chen Z,Zhong J,Ren X,et al.Involvement of a novel regulatory cascade consisting of SET-H3K18ac/H3K27ac-53BP1 in Cr(VI)-induced malignant transformation of 16HBE cells[J].Toxicology Letters,2021,339:70-77.
[51] Chen D,Kluz T,Fang L,et al.Hexavalent Chromium(Cr(VI))Down-Regulates Acetylation of Histone H4 at Lysine 16 through Induction of Stressor Protein Nupr1[J].PLoS One,2016,11(6):e0157317.
[52] Chittori S,Hong J,Bai Y,et al.Structure of the primed state of the ATPase domain of chromatin remodeling factor ISWI bound to the nucleosome[J].Nucleic Acids Research,2019,47(17):9400-9409.
[53] Vonhandorf A,Sanchez-Martin F J,Biesiada J,et al.Chromium disrupts chromatin organization and CTCF access to its cognate sites in promoters of differentially expressed genes[J].Epigenetics,2018,13(4):363-375.
[54] Ovesen J L,Fan Y,Zhang X,et al.Formaldehyde-Assisted Isolation of Regulatory Elements(FAIRE)analysis uncovers broad changes in chromatin structure resulting from hexavalent chromium exposure[J]. PLoS One, 2014, 9(5) :e97849.
[55] Goodall G J,Wickramasinghe V O.RNA in cancer[J].Nature Reviews Cancer,2020,21(1):22-36.
[56] Pratheeshkumar.P,Son,Y O,Divya S P,et al.Hexavalent chromium induces malignant transformation of human lung bronchial epithelial cells via ROS-dependent activation of miR-21-PDCD4 signaling[J]. Oncotarget, 2016, 7(32):51193-210.
[57] Wang Z,Lin H P,Li Y,et al.Chronic Hexavalent Chromium Exposure Induces Cancer Stem Cell-Like Property and Tumorigenesis by Increasing c-Myc Expression[J].Toxicological Sciences,2019,172(2):252-264.
[58] He J,Qian X,Carpenter R,et al.Repression of miR-143 mediates Cr(VI)-induced tumor angiogenesis via IGF- IR/IRS1/ERK/IL-8 pathway[J].Toxicological Sciences,2013,134(1):26-38.
[59] Hu G,Feng H,Long C,et al.LncRNA expression profiling and its relationship with DNA damage in Cr(VI)-treated 16HBE cells[J].Science of the Total Environment,2019,655:622-632.
[60] Zheng P,Kang Y,Han S,et al.A Novel Transcriptome Integrated Network Approach Identifies the Key Driver lncRNA Involved in Cell Cycle With Chromium(VI)-Treated BEAS-2B Cells[J].Frontiers in Genetics,2020,11:597803.

Cr(III)和Cr(VI)的表观遗传毒性分析

Epigenetic Toxicity Analysis of Cr(III) and Cr(VI)

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