3D打印胶原基材料及其在口腔组织再生修复中的应用

doi:10.19677/j.issn.1004-7964.2023.02.008

Leather Science and Engineering ›› 2023, Vol. 33 ›› Issue (2): 47-54.doi: 10.19677/j.issn.1004-7964.2023.02.008

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3D Printing of Collagen-based Materials and its Application in Regeneration and Repair of Oral Tissue

ZENG Yiwei¹, LIU Hai², SHA Chuanlu², ZHOU Jiajing², LI Hui^1,*

1. West China school of Stomatology, Sichuan University, Chengdu 610041, China;
2. College of Biomass Science and Engineering, Sichuan University, Chengdu 610065, China

Received:2023-02-06 Published:2023-04-01 Online:2023-03-21

Abstract

Abstract: 3D printing can be used to create scaffolds for promoting tissue repair and regeneration by precisely controlling the composition and spatial distribution patterns of cells and biomaterials. Collagen, an important component of the extracellular matrix in animal tissues, has been used as a 3D printing bioink for a variety of tissue regeneration due to its excellent biocompatibility. Defects in oral and craniomaxillofacial tissue can have a significant impact on the function and appearance of patients. However, current clinical treatments cannot restore their original anatomical structure and physiological function completely. This article reviews the current commonly used 3D bioprinting technologies, and the sources and extraction methods of collagen, cell-laden and cell-free collagen-based bioinks. The applications of 3D printed collagen-based materials in pulp-dentin complexes, periodontal tissues, bone, cartilage, and skin regeneration are highlighted. We also envision the future development of collagen-based bioinks for biomedicine applications.

Key words: 3D printing, collagen, oral tissue regeneration, tissue engineering, pulp-dentin complexes, periodontal regeneration, bone regeneration

CLC Number:

ZENG Yiwei, LIU Hai, SHA Chuanlu, ZHOU Jiajing, LI Hui. 3D Printing of Collagen-based Materials and its Application in Regeneration and Repair of Oral Tissue[J]. Leather Science and Engineering, 2023, 33(2): 47-54.

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3D Printing of Collagen-based Materials and its Application in Regeneration and Repair of Oral Tissue

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