纳米银复合抗菌剂的制备及其在抗菌裘皮中的应用

doi:10.19677/j.issn.1004-7964.2020.06.006

皮革科学与工程 ›› 2020, Vol. 30 ›› Issue (6): 34-39.doi: 10.19677/j.issn.1004-7964.2020.06.006

纳米银复合抗菌剂的制备及其在抗菌裘皮中的应用

温永汉¹, 杨威特², 张金伟², 孙宏斌³, 区棋铭¹, 陈武勇^2,*

1.广东省江门市质量计量监督检测所,广东江门 529000;
2.四川大学皮革化学与工程教育部重点实验室,四川成都 610065;
3.广东盛方化工有限公司,广东江门 529162

收稿日期:2020-04-30 出版日期:2020-12-28 上线日期:2020-12-02
通讯作者: *陈武勇(1952-),男,教授,wuyong.chen@163.com,主要从事鞣制化学,功能皮革,微生物及酶应用等领域研究工作。
作者简介:温永汉（1966-）,男,化工高级工程师,gdjmyonghan@163.com,主要从事轻工产品检验检测、新型轻工材料开发和利用等领域研究工作。
基金资助:
2020年度广东省市场监督管理局资助科研项目(2020ZZ15); 2020年四川大学实验技术立项项目

Preparation of Nano-silver Combined Antibacterial Agent and its Application on Antibacterial Sheep Fur

WEN Yonghan¹, YANG Weite², ZHANG Jinwei², SUN Hongbin³, OU Qiming¹, CHEN Wuyong^2,*

1. Guangdong Jiangmen Supervision Testing Institute of Quality and Metrology, Jiangmen 529000, China;
2. Key Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Chengdu 610065, China;
3. Guangdong Shengfang Chemical Corporation, Jiangmen 529162, China

Received:2020-04-30 Published:2020-12-28 Online:2020-12-02

摘要/Abstract

摘要： 为了提高纳米银抗菌剂的抗菌性,选用高效、低毒的异噻唑啉酮与纳米银溶液进行复配,通过紫外-可见光谱、动态光散射和透射电镜研究了异噻唑啉酮加入量对纳米银稳定性的影响,然后通过对六种细菌的抗菌实验,寻找最优的复配方案。制得的纳米银复合抗菌剂用于绵羊裘皮抗菌整理,完成整理后对抗菌剂吸收率以及绵羊裘皮抗菌性能进行检测,同时对经过多次抗菌整理后绵羊裘皮的力学性能进行了测试。研究结果表明,当混合体系中异噻唑啉酮的浓度不超过20 μg/mL时,可获得稳定的纳米银复合抗菌剂。复配协同指数显示纳米银与异噻唑啉酮的复配具有协同或加合作用。将纳米银复合抗菌剂用于绵羊裘皮抗菌处理,整理过程中纳米银吸收率高,整理后绵羊裘皮对金黄色葡萄球菌、大肠杆菌和红圆酵母都具有快速、明显的抑菌效果。经过10次抗菌整理后,绵羊裘皮的力学性能无显著变化。总之,异噻唑啉酮与纳米银复配,可以制备具有高效、广谱抗菌能力的抗菌剂,可成为生产抗菌裘皮和皮革的新选择。

关键词: 纳米银, 异噻唑啉酮, 复合抗菌剂, 绵羊裘皮, 抗菌性

Abstract: To improve the antibacterial property of nano-sliver, a high effective and low toxicity isothiazolinone was chosen to develop a combined antibacterial agent. Effect of isothiazolinone concentration on nano-sliver stability was evaluated by using the UV-Vis, dynamic light scattering and transmission electron microscope analysis. Then, six kinds of bacteria were used to optimize the component of combined antibacterial agent. The optimized combined antibacterial agent was used to treat sheep fur. The exhaustion rate of combined antibacterial agent and antibacterial property of treated fur were tested, and the mechanical properties of sheep fur subjected to several antibacterial treatments were also determined. The results showed that stable combined antibacterial agent could be obtained when the concentration of isothiazolinone in the mixture was below 20 μg/mL. The synergy index indicated there were synergistic effects and adducts actions for combining nano-sliver and isothiazolinone. During the antibacterial treatment of sheep fur by combined antibacterial agent, the exhaustion rate was high, and the treated fur exhibited rapid and effective antibacterial property against Escherichia coli, Staphylococcus aureus and Rhodotorula mucilaginosa. Moreover, there was no negative effect on mechanical properties of sheep fur even after 10 times antibacterial treatments. In sum, the combination between nano-sliver and isothiazolinone could prepare high efficiency and broad-spectrum antibacterial agent, and the combined antibacterial agent might be new choice for producing antibacterial leather and fur.

Key words: nano-sliver, isothiazolinone, combined antibacterial agent, sheep fur, antibacterial property

中图分类号:

TS529.1

温永汉, 杨威特, 张金伟, 孙宏斌, 区棋铭, 陈武勇. 纳米银复合抗菌剂的制备及其在抗菌裘皮中的应用[J]. 皮革科学与工程, 2020, 30(6): 34-39.

WEN Yonghan, YANG Weite, ZHANG Jinwei, SUN Hongbin, OU Qiming, CHEN Wuyong. Preparation of Nano-silver Combined Antibacterial Agent and its Application on Antibacterial Sheep Fur[J]. Leather Science and Engineering, 2020, 30(6): 34-39.

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纳米银复合抗菌剂的制备及其在抗菌裘皮中的应用

Preparation of Nano-silver Combined Antibacterial Agent and its Application on Antibacterial Sheep Fur

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