Cr(III)和Cr(VI)的表观遗传毒性分析

doi:10.19677/j.issn.1004-7964.2022.04.008

Leather Science and Engineering ›› 2022, Vol. 32 ›› Issue (4): 47-53.doi: 10.19677/j.issn.1004-7964.2022.04.008

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Epigenetic Toxicity Analysis of Cr(III) and Cr(VI)

WANG Qin^1,2, HE Yunxiang², GONG Guidong², YANG Bin¹, WANG Nan¹, ZHANG Yaoyao³, GU Jian^1,*

1. School of Pharmacy, Southwest Minzu University, Chengdu 610225, China;
2. College of Biomass Science and Engineering, Sichuan University, Chengdu 610065, China;
3. Reproductive Center, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China

Received:2021-10-12 Published:2022-08-28 Online:2022-07-11

Abstract

Abstract: Chromium is an essential trace element in human body, and its ion valence state is closely related to its effect on human body. Trivalent chromium is the most stable state of chromium in nature. It can be used as a co-factor of insulin to regulate the metabolism of sugar, fat and protein, and has no epigenetic toxicity to human body. Howerver, hexavalent chromium, a carcinogen, poses a serious threat to human health by interfering with epigenetic patterns such as DNA methylation, histone modification, chromosomal remodeling and non-coding RNA regulation. This review is of great significance to fully understand the biological functions of trivalent chromium and the epigenetic toxicity of hexavalent chromium.

Key words: chromium, trace element, insulin, epigenetic

CLC Number:

R394.3

WANG Qin, HE Yunxiang, GONG Guidong, YANG Bin, WANG Nan, ZHANG Yaoyao, GU Jian. Epigenetic Toxicity Analysis of Cr(III) and Cr(VI)[J]. Leather Science and Engineering, 2022, 32(4): 47-53.

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Epigenetic Toxicity Analysis of Cr(III) and Cr(VI)

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