Leather Science and Engineering ›› 2021, Vol. 31 ›› Issue (2): 16-22.doi: 10.19677/j.issn.1004-7964.2021.02.004

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A Review: Microbial Collagenase

WANG Xuechuan1, WANG Xueying1, YANG Shuqin2, HE Fangfang1   

  1. 1. Institute of Biomass & Functional Materials , College of Bioresources Chemical and Material Engineering, Shaanxi University of Science & Technology, Xi’an, 710021, China;
    2. Zibo Dahuanjiu Polygrace Leather Group Co. Ltd., Zibo 255000, China
  • Received:2020-07-02 Published:2021-04-28 Online:2021-03-30

Abstract: Collagenase is highly specific and plays a key role in the overall degradation of animal extracellular matrix due to its ability to degrade collagen. This review introduced the classification and structure of collagenase, and expounded the techniques and methods used in the activity determination, gene cloning, expression, purification and characterization of microbial collagenase. The application and prospect of collagenase was then summarized in leather industry, medical industry, cell separation and other fields. Finally, the existing problems for collagenase were briefly summarized, and the future development direction was prospected.

Key words: microorganism, collagenase, classification, application, research progress

CLC Number: