Abstract: Microfiber synthetic leather is highly favored for its excellent comprehensive performance. However, common microfiber synthetic leather on the current market is mostly based on staple fiber-needle-punched nonwovens, and little research has been done on the leather products made of filament nonwovens. In order to explore the feasibility of applying microfiber filament nonwovens to leather products, this paper prepared sea-island and segmented-pie filament nonwovens for fabricating their leather products. We then compared and discussed the properties of sea-island and segmented-pie filament nonwovens and their leather products. The results show that the tensile properties of sea-island filament nonwovens and their leather products are inferior to that of segmented-pie filament nonwovens and their leather products, while the softness, air permeability, and moisture permeability are better than segmented-pie filament nonwovens and their leather products. In conclusion, sea-island filament nonwovens are more suitable for the preparation of microfiber leather.