Abstract: A rapid method was established for the determination of 26 residual harmful solvents in shoe products, in which methanol was used as the extraction solvent and the sample was extracted by ultrasonic at room temperature. The filtrate was analyzed by gas chromatography-mass spectrometry (GC-MS) with selective ion mode and quantified by external standard method. In this method, the limits of detection for the target substances were 1.0-5.0 mg/kg; the linear range was 0.50-25.0 mg/L; the average recovery was 85.2%-106.7%, and the relative standard deviation was 2.1%-7.2%. This method has the advantages of simple operation, rapid and high sensitivity, and is suitable for the detection of various shoe materials. It can determine a wide variety of restricted harmful organic solvents and meet the requirements for the determination of residual harmful organic solvents in footwear products in domestic and foreign regulations.