Abstract: Bacterial erosion can not only affect the performance of leather goods, but also do harm to the health of consumers. Adding antibacterial agents is an effective strategy to reduce the occurrence of this problem. However, traditional antibacterial agents usually have single target that locates inside bacteria. In this case, bacteria could acquire drug-resistance through multiple mechanisms. The emerging two-dimensional materials (e.g. graphene oxide, molybdenum disulfide, two-dimensional transition metal carbon/nitride, black phosphorus, carbon nitride, etc.) have synergistic antibacterial mechanisms, such as physical destruction of cell membrane, physical wrapping, and oxidative stress, which hold the potency for inhibiting the occurrence of drug-resistance. This paper summarized the current research progress on the two-dimensional antibacterial materials worldwide, and prospected the application of such new antibacterial materials in leather finishing.