Abstract: A HPLC analytical method was established for the determination of phenol and bisphenol A in synthetic materials for footwear. Methanol was used as the extraction solvent and the ultrasonic extraction was adopted to extract phenol and bisphenol A in synthetic materials, and the conditions of instrument analysis and sample pretreatment were optimized. The results showed that the linear range of the method was 0.1-5.0 μg/mL; the detection limit was 0.4-3.6 mg/kg; the adding standard recoveries ranged from 92.4% to 99.6%, and the relative standard deviation was at the range of 3.1%-6.9%. Phenol or bisphenol A was detected in 10 of 80 batches of commercial synthetic material samples for footwear, and the detection rate was 12.5%. The possible introduction routes of phenol and bisphenol A are antioxidants, stabilizers and plasticizers used in the processing of polyvinyl chloride and polyurethane. This method is easy to operate and fast to analyze and is suitable for the detection of phenol and bisphenol A in synthetic materials for footwear.