Abstract: A headspace GC-MS method for the determination of 9 organic solvents in leather and its products was established. Sample of leather was equilibrated in a head-space bottle at 80 ℃ for 60 min, then the sample was introduced into the GC-MS for analysis. The method was quantified by external standard with matrix calibration curves. Test for recovery were made by standard addition method on the base of leather samples, and recovery were ranged from 82.9% to 106.5%, with the relative standard deviation (RSD) ranged from 1.7% to 8.9%, and the detection limit was 0.11-0.68 mg/kg. This method is simple, and the results are accurate and sensitive. Compared with the direct injection method, this method could avoid the pollution of instrument system, and good results were achieved by applying this method in actual leather products.