Abstract: The wood protein glue is prepared by using the collagen degradation product extracted from the waste leather shavings by the alkaline method as the raw material and epichlorohydrin as the cross-linking agent. By controlling the amount of epichlorohydrin, reaction temperature, reaction time and pH orthogonal method to synthesize protein glue (CA). Optimize the synthesis conditions by evaluating the viscosity of CA glue and the bonding strength of plywood. The CA adhesive synthesized under the optimized conditions has a solid content of about 42.0% and a viscosity of 1.56 Pa·s. The main quality indicators of plywood meet the requirements of Type I and Type II in GB/T9846-2015.