Abstract: Mixing fluorinated and hydrocarbon surfactants, serving as an important strategy to improve their performances and reduce their cost of use, has great significance for expanding the applications range of fluorinated surfactants. Based on the types of fluorinated surfactants, this article reviews the research progress of the fluorinated surfactants mixed systems and their applications in leather, petroleum and firefighting. At the same time, the development direction in the field of fluorinated surfactants mixed systems is prospected.