Abstract: The purpose of this paper is to explore the influence of arch structure and running shoe type on foot pressure distribution. Seven subjects with normal arch, 7 subjects with flat arch and 7 subjects with high arch were selected to wear three different types of running shoes (cushioned shoes, motion control shoes, stable shoes). Plantar pressure distribution was measured at a speed of 3 m / s when running on the treadmill. The peak pressure, contact area and pressure time integral were analyzed with two-way analysis of variance (ANOVA) with repeated measures. The interaction of foot arch structure and running shoe type on the contact area of the forefoot area was significant, and the contact area of forefoot area of the people with high arched foot was the largest when wearing cushioning shoes, and the influence of the foot arch structure on the peak pressure of the heel region was significant. The type of running shoes had significant effect on every parameter. Conclusion: The effect of shoe type on the dynamic parameter of the foot weakened the difference of arch structure, which may be helpful to prevent sports injury.