Abstract: Hollow microspheres are widely used in medicine, coatings, batteries and other fields because of their light weight, porosity and large specific surface area. It is a research hotspot in the field of nanomaterials. This article reviews the common preparation methods of hollow microspheres and their related structural features, and mentions the application of hollow microspheres as coatings, fillers and adsorbents in the leather industry. Facing the urgent demands of the modern light-weight, high-quality and environmentally-friendly leather product market, the potential significance of developing hollow microspheres in the leather field has been expressed.