Abstract: High shrinkage polyester (HSPET)/polyamide 6 (PA6) hollow pie-segmented spunbonded needle-punching microfiber leather base cloth (hereinafter referred to as HSPET/PA6 needle-punching leather base cloth) was prepared by using HSPET/PA6 spunbonded filament needle-punching nonwovens as the base cloth, and water-impregnated polyurethane (WPU) was included. The effects of the pre-fiber-splitting and post-fiber-splitting processes, as well as the immersion of polyvinyl alcohol (PVA) and WPU on the properties of HSPET/PA6 needle- punching leather base cloth were comparatively analyzed. The results showed that, under the same PVA and WPU leaching content, the mechanical properties of the pre-fiber-opening method were better than those of the post-fiber-opening method, but the softness and air permeability and moisture permeability were poorer compared with those of the post-fiber-opening method; the mechanical properties of the HSPET/PA6 needle-punching leather base cloth prepared under the two processes were improved and then decreased with the increase of the PVA leaching content, and were gradually increased with the increase of the WPU content; the softness and air permeability and moisture permeability were improved with the increase of PVA leaching content.