Abstract: Hexavalent chromium (Cr(VI)) is one of the typical heavy metal pollutants in industrial wastewater, which can be absorbed by human being easily and has great biological toxicity. Photocatalysis is an efficient and clean method for Cr(VI)removal. In order to improve the efficiency of photocatalysts, the defect synthesis of UiO-66 with trifluoroacetic acid as the regulator was carried out by solvothermal method to increase the specific surface area and photogenic electron mobility. The influence of regulator dosage on the morphology and structure of UiO-66 were observed by XRD, SEM, BET, TGA and other characterization methods, and the photocatalytic reduction of Cr(VI) of acid adjusted UiO-66 was investigated. The results showed that the acid-adjusted UiO-66 was octahedral with a specific surface area of 849.6 cm²/g. Under visible light irradiation, the photocatalytic reduction rate of acid-adjusted UiO-66 increased by 2.21 times. In addition, free radical capture experiments indicated that photo-generated electrons (e^-) and superoxide radicals (·O₂^-) were the main active components for photoreduction of Cr(VI).