Abstract: The Twentieth Party Congress conducted the deployment to promote the comprehensive revitalization of the countryside, and industrial revitalization is the key. China's leather industry, as an important livelihood industry, is closely related to agriculture, rural areas and farmers. The article put forward the concept of self-development ability of leather industry and discussed how enterprises and the industry can rely on internal forces to promote their growth when policy support was weakened. Using the coupling coordination degree model, Kernel density estimation, Dagum Gini coefficient decomposition method and others, this paper analyzed the coupling coordination level between China's leather industry self-development ability and rural revitalization from 2012 to 2022. The research results revealed that the time trend of the coupling coordination degree of the two was stable, but the geographical difference was obvious. The coupling coordination degrees in the east and central regions were higher than the national level. The inter-regional differences mainly originated from the east-west and east-northeast regions, and leather industry had a stronger driving force of self-development ability. In order to promote the synergistic development of leather industry and rural revitalization, the targeted countermeasures recommendations should be put forward starting from strengthening regional collaboration and the main driving factors.