Abstract: The Dong ethnic group's "Dongdong tui" Nuo mask, as the material carrier of Dong traditional art and religious ceremonies, not only inherits a unique artistic style, but also contains a rich cultural essence. By comprehensive application of interdisciplinary research methods such as memetics, Analytic hierarchy process and grounded theory, combined with the needs of users, the artistic elements of "Dongdong tui" Nuo mask were transformed into the design elements of leather cultural and creative products, trying to enhance the artistic value of leather products and the unique charm of the national culture. This study not only expands the application scope of the "Dongdong tui" Nuo mask culture in the field of modern leather goods design, but also opens new ideas and practical directions for the modern inheritance and innovative development of the local national culture.